Clinical TrialNeuroimaging & Brain MeasuresCompleted

The NeXT Study

This naturalistic observational study (n=225) investigates possible neurotoxic effects of recreational MDMA (ecstasy) on the human brain using imaging and cognitive measures.

Target Enrollment
225 participants
Study Type
Phase NA observational
Design
Non-randomized

Detailed Description

Prospective and retrospective components assess causality, course and clinical relevance of MDMA-related neurotoxicity. Cohorts include high-risk MDMA-naïve individuals followed for incident use, retrospectively selected exposed/unexposed participants, and a cross-sectional group with varied drug histories.

Outcomes include neuroimaging (SPECT, 1H-MRS, fMRI, perfusion MRI) and clinical measures of memory, mood and personality, controlling for confounders.

Participants

Ages
18 – 35
Sexes
Male & Female

Inclusion Criteria

  • Inclusion Criteria:
  • between 18 - 35 years of age

Exclusion Criteria

  • Exclusion Criteria:
  • severe medical or neuropsychiatric illness
  • use of prescribed psychotropic medications such as SSRI's
  • use of intravenous drugs
  • pregnancy
  • contra-indications for MRI investigation

Study Details

  • Status
    Completed
  • Phase
    Phase NA
  • Type
    observational
  • Design
    Non-randomized
  • Target Enrollment225 participants
  • Timeline
    Start: 2002-04-01
    End: 2005-07-01
  • Topic
    Neuroimaging & Brain Measures

Locations

Bonger Institute of Criminology — Amsterdam, North Holland, Netherlands
Academic Medical Center Amsterdam — Amsterdam, North Holland, Netherlands
University Medical Center Utrecht — Utrecht, Utrecht, Netherlands

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