Clinical TrialDepressive DisordersTemporarily not available

Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine Treatment

This treatment trial (n=40) aims to enhance depression relief among patients already undergoing esketamine treatment by introducing computer-based cognitive training.

Target Enrollment
40 participants
Study Type
Phase NA interventional
Design
Randomized, quadruple Blind

Detailed Description

Randomised, quadruple-blind, parallel-group study in patients receiving clinical esketamine comparing eight sessions of web-based cognitive training versus sham training; primary aim is improved depressive symptoms.

Intervention delivered remotely via computer; results could support scalable adjunctive strategies to augment esketamine treatment for depression.

Study Protocol

Preparation

sessions

Dosing

sessions

Integration

sessions

Therapeutic Protocol

other

Study Arms & Interventions

Cognitive Training

experimental

8 sessions of web-based cognitive training adjunctive to clinical esketamine treatment.

Interventions

  • Compound
    via Other• 8 sessions• 8 doses total

    Web-based computerised cognitive training delivered over eight sessions.

Sham Training

active

8 sessions of web-based sham training as comparator.

Interventions

  • Compound
    via Other• 8 sessions• 8 doses total

    Web-based sham training delivered over eight sessions.

Participants

Ages
18 – 80
Sexes
Male & Female

Inclusion Criteria

  • Any patient aged 18-80 in the esketamine clinic in the Center for Interventional Psychiatry. The clinic's extensive screening and eligibility criteria for esketamine treatment will not be altered in any way, other than imposing the study-specific age range and the two exclusion criteria below.

Exclusion Criteria

  • 1. Patients who do not expect to remain located in the Pittsburgh area for a minimum of 1 month beyond study enrollment.
  • 2. Patients who, in the judgment of the esketamine clinical medical director, show signs of intellectual disability, developmental disability, and/or cognitive impairment (including age-related cognitive decline) of a sufficient degree to interfere with engagement in any study procedure.

Study Details

  • Status
    Temporarily not available
  • Phase
    Phase NA
  • Type
    interventional
  • Design
    Randomizedquadruple Blind
  • Target Enrollment40 participants
  • Timeline
    Start: 2023-02-14
    End: 2025-08-01
  • Topic
    Depressive Disorders

Locations

Western Psychiatric Institute and Clinic — Pittsburgh, Pennsylvania, United States

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