Mood Effects of Serotonin Agonists Extended
Triple-blind, randomised, parallel trial (n=56) testing four repeated very low doses of LSD (13 µg or 26 µg) versus placebo in healthy adults 18–40 to assess mood, cognitive performance and responses to emotional tasks.
Detailed Description
Randomised, triple-blind, parallel-group study in healthy adults examining repeated very low doses of lysergic acid diethylamide (13 µg and 26 µg) versus placebo across four sessions spaced 3–4 days apart.
Outcomes include mood measures, cognitive performance and emotional task responses; actual enrolment recorded as 56 participants.
Study Protocol
Preparation
Dosing
Integration
Study Arms & Interventions
Placebo
inactivePlacebo (solution)
Interventions
- Placebovia Oral• every 3-4 days (4 sessions)• 4 doses total
Placebo solution
LSD 13 µg
experimental13 µg lysergic acid diethylamide, repeated low-dose schedule
Interventions
- LSD13 µgvia Oral• every 3-4 days (4 sessions)• 4 doses total
Four repeated low doses at 3–4 day intervals
LSD 26 µg
experimental26 µg lysergic acid diethylamide, repeated low-dose schedule
Interventions
- LSD26 µgvia Oral• every 3-4 days (4 sessions)• 4 doses total
Four repeated low doses at 3–4 day intervals
Participants
Inclusion Criteria
- Inclusion Criteria:
- English fluency
- High school level education
- BMI between 19 and 30
Exclusion Criteria
- Exclusion Criteria:
- Diagnosed medical condition
- women who are nursing, pregnant, or plan to become pregnant within 3 months
- History of psychotic disorder or family history of psychotic disorder
Study Details
- StatusCompleted
- PhasePhase I
- Typeinterventional
- DesignRandomizedtriple Blind
- Target Enrollment56 participants
- TimelineStart: 2019-04-20End: 2021-06-07
- Compounds
- Topic