Low Dose Ketamine Infusion for the Treatment of Resistant Depression
Observational prospective cohort collecting outcomes after low-dose IV ketamine infusions for treatment-resistant depression in admitted adult patients.
Detailed Description
Prospective descriptive study extracting electronic health record data on adults with treatment-resistant depression who receive physician-ordered ketamine infusions in hospital settings; assessments include QIDS pre and 24 hours post infusion and vital signs monitoring.
Ketamine is administered IV in 50 mL normal saline at either 0.5 mg/kg over 40 minutes or 1 mg/kg over 90 minutes per ICU attending decision; monitoring includes vitals every 15 minutes during infusion and until recovery.
Study Protocol
Preparation
Dosing
Integration
Study Arms & Interventions
Low-dose ketamine
experimentalSingle-infusion IV ketamine per physician orders for patients with treatment-resistant depression (observational cohort).
Interventions
- Ketamine0.5 - 1 mg/kgvia IV• single dose• 1 doses total
Infusion in 50 mL NS; 0.5 mg/kg over 40 minutes or 1 mg/kg over 90 minutes as determined by ICU attending.
Participants
Inclusion Criteria
- Inclusion Criteria:
- Treatment resistant depression (identified by psychiatric consult using QIDS assessment)
- Adult patients (18–89 years) admitted to medical floor with acceptance to local Behavioural Medical Center
- No history of psychosis
- No active substance use
- Assessed and approved for ketamine bolus by Psychiatry and ICU attending
Exclusion Criteria
- Exclusion Criteria (relative contraindications per SICU/ER attending):
- Coronary artery disease
- Increased intraocular pressure (glaucoma)
- Increased intracranial pressure
- Uncontrolled hypertension
- Kidney dysfunction
- Liver dysfunction
- Cardiac decompensation
- Psychotic disorders (requires further evaluation)
Study Details
- StatusWithdrawn
- Typeobservational
- DesignNon-randomized0
- TimelineStart: 2020-06-29End: 2020-12-29
- Compound
- Topic