Ketamine Infusion Therapy for the Treatment of PTSD in Paramedics
Observational prospective cohort (n=7) evaluating change on psychological screening tools before, after, and 30 days following a six-infusion ketamine series in paramedics with work-related PTSD.
Detailed Description
Paramedics with PTSD related to prehospital work receive a series of six one-hour ketamine hydrochloride infusions over three weeks; assessments occur before treatment, after the series, and 30 days post-treatment to assess durability.
Outcome measures include PHQ-9, PCL-5, AUDIT, BAI administered pre/post/30 days, plus RMEQ-30 and a single-item experiential impact survey after the infusion series; study is a prospective cohort (non-probability sample).
Study Protocol
Preparation
Dosing
Integration
Study Arms & Interventions
Ketamine infusions
experimentalSix one-hour ketamine infusions administered over three weeks.
Interventions
- Ketaminevia IV• series (six infusions over 3 weeks)• 6 doses total
Six one-hour IV infusions; dose per site protocol (not specified in registry fragment).
Participants
Inclusion Criteria
- Inclusion Criteria:
- Must have worked as a paramedic (EMT-P) on a 911 prehospital service for at least five years.
- Must be diagnosed with post traumatic stress disorder that happened as a result of working as a paramedic
- Diagnosis must have been made by a mental health professional
- The symptoms of PTSD must be having a significant adverse effect on the subject's life
- Subjects must be able to speak and read English
Exclusion Criteria
- Exclusion Criteria:
- Currently participating in another PTSD treatment program and/or research study
- Diagnosis of psychosis
- Uncontrolled hypertension or a history of heart failure