Clinical TrialKetamineCompleted

Intranasal dexmedetomidine versus intranasal ketamine for prevention of emergence agitation after sevoflurane anesthesia in pediatric patients undergoing myringotomy : a randomized clinical trial.

This randomised controlled trial (n=90) evaluated the safety and efficacy of ketamine for emergence agitation after sevoflurane anesthesia in children using 350mg/70kg ketamine.

Target Enrollment
90 participants
Study Type
interventional
Design
Randomized

Detailed Description

The aim of this prospective randomized study is to compare the effect of intranasal dexmedetomidine and intranasal ketamine for prevention of emergence agitation after sevoflurane anesthesia in pediatric patients scheduled for myringotomy operations.

Study Arms & Interventions

Experimental Arm

experimental

Interventions

  • Ketamine

Participants

Inclusion Criteria

  • Patients prepared to unilateral or bilateral myringotomy
  • Both sexes, age from 3 to 6 years old.
  • ASA physical status I or II.

Exclusion Criteria

  • a -Parent's refusal.
  • b- Preoperative agitation (e.g. cerebral palsy, agitation…etc).
  • c - Children with allergy to ketamine, dexmedetomidine.
  • d - Aberrant nasal deformity or nasal trauma.
  • e - Acute (e.g. running nose or upper respiratory tract infection) or chronic nasal problems.
  • f -Mental retardation, physical developmental delay, or neuromuscular disease.
  • g - Patients under treatment with sedatives or anticonvulsants.
  • h - Respiratory and cardiovascular diseases.

Study Details

  • Status
    Completed
  • Type
    interventional
  • Design
    Randomized
  • Target Enrollment90 participants
  • Timeline
    Start: 2016-02-02
    End: 2016-05-26
  • Compound
    Ketamine

Locations

Unknown facility — Australia

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