Clinical TrialHealthy VolunteersMDMAPlaceboMDMAPlaceboPlaceboCompleted

Effects of MDMA on Emotional and Social Memories

The purpose of this study is to examine the effects of MDMA on encoding and retrieval of emotional and social memories in healthy young adults.

Target Enrollment
84 participants
Study Type
Phase NA interventional
Design
Randomized, triple Blind

Detailed Description

Between-subjects, randomized, triple-blind, placebo-controlled parallel design (N=84) with three groups: MDMA at encoding, MDMA at retrieval, and placebo at both sessions.

Participants attend two sessions 48 hours apart; MDMA (1 mg/kg, oral) is administered either before encoding or before retrieval, and memory tested via surprise verbal recall and picture recognition alongside mood questionnaires.

Study Protocol

Preparation

sessions

Dosing

2 sessions

Integration

sessions

Study Arms & Interventions

MDMA at Encoding

experimental

MDMA administered before encoding; placebo at retrieval two days later.

Interventions

  • MDMA1 mg/kg
    via Oral• single dose

    MDMA given before encoding session (single administration).

  • Placebo
    via Oral• single dose

    Placebo capsule (given at retrieval).

MDMA at Retrieval

experimental

Placebo before encoding; MDMA administered before retrieval two days later.

Interventions

  • MDMA1 mg/kg
    via Oral• single dose

    MDMA given before retrieval session (single administration).

  • Placebo
    via Oral• single dose

    Placebo capsule (given at encoding).

Placebo at both sessions

inactive

Placebo capsules at both encoding and retrieval sessions.

Interventions

  • Placebo
    via Oral• single dose

    Placebo at both sessions.

Participants

Ages
18 – 40
Sexes
Male & Female

Inclusion Criteria

  • Normal healthy males and females, aged 18-40 years.

Exclusion Criteria

  • 1. Any current medical condition requiring medication or abnormal electrocardiogram
  • 2. Current or past medical condition considered to be a contraindication for the study conditions
  • 3. Any current Axis I psychiatric disorder (including Substance Use Disorder), or Anxiety Disorder or Major Depression in the past year, any history of psychosis
  • 4. Less than high school education
  • 5. Lack of fluency in English
  • 6. Night shift work
  • 7. Pregnancy, lactation, or plans to become pregnant
  • 8. Use of hormonal contraception

Study Details

Your Library