Clinical TrialHealthy VolunteersPlaceboMDMAMDMAPlaceboCompleted

Effect of Stimulant Drugs on Social Perception

Randomised, double-blind crossover study (n=36) comparing single doses of MDMA (0.75 mg/kg and 1.5 mg/kg), methamphetamine (20 mg) and placebo in healthy volunteers to assess prosocial effects.

Target Enrollment
36 participants
Study Type
Phase I interventional
Design
Randomized, double Blind

Detailed Description

Randomised, double-blind, crossover within-subject design in healthy volunteers comparing placebo, low-dose MDMA (0.75 mg/kg), high-dose MDMA (1.5 mg/kg) and methamphetamine (20 mg).

Primary aim is to characterise the uniquely social or prosocial effects of MDMA versus a prototypical stimulant; outcomes include behavioural social measures and acute subjective and physiological responses.

Study Protocol

Preparation

sessions

Dosing

4 sessions

Integration

sessions

Study Arms & Interventions

Placebo

inactive

Single placebo capsule session.

Interventions

  • Placebo
    via Oral• single dose• 1 doses total

    Placebo capsule.

Low dose MDMA

experimental

Single 0.75 mg/kg MDMA session.

Interventions

  • MDMA0.75 mg/kg
    via Oral• single dose• 1 doses total

High dose MDMA

experimental

Single 1.5 mg/kg MDMA session.

Interventions

  • MDMA1.5 mg/kg
    via Oral• single dose• 1 doses total

Methamphetamine

active comparator

Single 20 mg methamphetamine session.

Interventions

  • Placebo20 mg
    via Oral• single dose• 1 doses total

    Methamphetamine 20 mg (active comparator).

Participants

Ages
18 – 35
Sexes
Male & Female

Inclusion Criteria

  • High school degree
  • English fluency
  • Healthy
  • Has used MDMA
  • Age 18–35

Exclusion Criteria

  • Pregnant or trying to become pregnant
  • Any medical or psychiatry condition

Study Details

Locations

University of Chicago — Chicago, Illinois, United States

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