Clinical TrialNeurocognitive DisordersKetamineCompleted
Effect of Low Dose Ketamine on Postoperative Cognitive Dysfunction in Geriatric Patients Undergoing Abdominal Surgery
This randomised controlled trial (n=40) evaluated the safety and efficacy of ketamine for cognitive dysfunction abdominal surgery using 35mg/70kg ketamine.
Target Enrollment
40 participants
Study Type
interventional
Design
Randomized, triple Blind
Registry
Detailed Description
Forty patients aged 65 and older planned for elective abdominal surgery were randomly divided into two groups. While 5 ml- physiological serum was administered to the control group, ketamine group received 0,5 mg/kg ketamine in IV form 5 minutes before induction. Hemodynamic variables,were measured every 15 min until the end of the operation. Standardized Mini Mental Test (SMMT) were performed 24 hours prior to the operation and repeated 1 hour and 6hours after the operation to evaluate the cognitive functions.
Study Arms & Interventions
Experimental Arm
experimentalInterventions
- Ketamine
Participants
Inclusion Criteria
- Patients aged 65 and older,
- who were at least literate,
- fell under the ASA I-II risk group
Exclusion Criteria
- Patients who had significant coronary, pulmonary, renal, hepatic diseases, neuropsychiatric diseases affecting the CNS and cognitive functions, fever and infection, metabolic and endocrinal diseases, malnutrition and dehydration, low levels of vitamin B12 and folate;those who took medications that affected CNS, who were alcohol and substance addicts, smokers, urgent cases, patients in the risk group of ASA III and above, patients younger than 65, those who scored 23 and lower in the SMMT (Standardized Mini Mental Test) performed one day before the operation were excluded from the study.
Study Details
- StatusCompleted
- Typeinterventional
- DesignRandomizedtriple Blind
- Target Enrollment40 participants
- TimelineStart: 2012-07-01End: 2012-12-31
- Compound
- Topic
Locations
Unknown facility — Australia