Patient-Centered Outcomes Research Institute

The Patient-Centered Outcomes Research Institute (PCORI) is a Washington, DC–based independent non-profit (501(c)(1)) created by the 2010 Affordable Care Act to fund comparative effectiveness research. PCORI awarded $12.6 million to Yale University researchers to directly compare IV racemic ketamine versus intranasal esketamine (Spravato) for treatment-resistant depression, and separately funded the ELEKT-D ketamine vs. ECT effectiveness trial conducted through the Cleveland Clinic Foundation.