Global Coalition for Adaptive Research

The Global Coalition for Adaptive Research (GCAR) is a US non-profit that serves as regulatory sponsor for adaptive platform trials, including GBM AGILE (glioblastoma) and the DOD-backed M-PACT (NCT05422612), which simultaneously evaluates multiple pharmacotherapies for PTSD in active-duty service members and veterans. GCAR modernizes drug development by replacing ineffective arms with new candidates within a single master protocol.