Urs Duthaler
Clinical Pharmacologist and Researcher
Papers
Trials
Key Impact
Noted for advancing human experimental psychedelic research through rigorous, placebo-controlled studies and investigations into the pharmacokinetics and metabolism of classic serotonergic psychedelics.
Background & Research
Urs Duthaler is a clinical pharmacologist and researcher who has played a central role in contemporary human experimental studies of classic serotonergic psychedelics. Working frequently in collaboration with Matthias E. Liechti and other Swiss research groups, he has contributed to a series of randomized, double-blind, placebo-controlled cross-over trials in healthy volunteers examining acute, dose-dependent effects of LSD, intravenous DMT, co‑administration of MDMA and LSD, and head‑to‑head comparisons of mescaline, LSD and psilocybin. These studies emphasise careful pharmacological characterisation, robust blinding and standardised psychometric and physiological assessments, informing both basic neuropharmacology and clinical translational efforts.