Thomas Lyons

Thomas Lyons is a clinical researcher whose recent work focuses on experimental and clinical studies of psilocybin in both healthy volunteers and people with treatment-resistant depression. Using controlled experimental designs, Lyons has contributed to investigations of acute physiological and psychological moderators of psychedelic-induced personality change, examined whether body mass index predicts subjective or clinical responses to psilocybin, and explored early brain changes following first-time psilocybin use. His project portfolio spans mechanistic questions about how individual differences shape acute and longer-term outcomes and applied clinical questions about therapeutic effects in depressive disorders.

Lyons' publications and trial activity in the available database emphasise measurable psychological and behavioural outcomes — for example, alterations in nature relatedness and shifts in authoritarian political attitudes after psilocybin therapy, and changes in forecasting of future life events following treatment for depression. His work is oriented towards clarifying moderators and mediators of psychedelic effects to improve participant selection, risk mitigation and interpretation of treatment mechanisms in future clinical trials.