Nathan Sepeda
Clinical Researcher
Papers
Trials
Key Impact
Notable for his contributions to clinical and experimental studies of psilocybin-assisted interventions, including trials of major depressive disorder and investigations of enduring psychological and neurofunctional effects.
Background & Research
Nathan D. Sepeda is a clinical researcher specialising in clinical trials and outcome measurement within psychedelic medicine. He has been a frequent collaborator on multi‑centre and single‑site investigations into the psychological and neurofunctional effects of classic and atypical hallucinogens, contributing to work on psilocybin‑assisted therapy for major depressive disorder, healthy‑volunteer pharmacology studies, and longer‑term follow‑up safety and efficacy assessments. Sepeda's work spans experimental double‑blind comparisons, prospective 12‑month outcome monitoring, and targeted studies of spiritual and religious experience in diverse populations.
His research emphasis is on quantifying experience‑dependent and enduring psychological changes after psychedelic administration and identifying predictors of treatment response. Sepeda has co‑authored pivotal publications from programmes affiliated with major psychedelic research centres and applies interdisciplinary methods — clinical trial design, standardised psychological measures and neurobehavioural assessments — to clarify therapeutic potential, adverse effects and mechanisms of change in psychedelic‑assisted interventions.