Mariana Yonamine

M. Yonamine (published as Yonamine, M.) is a clinical researcher active in early-stage, experimental clinical trials examining the psychopharmacology and therapeutic potential of ayahuasca in humans. Their work centres on pilot, proof-of-concept and feasibility studies that employ randomised, placebo-controlled or single-blind designs in both clinical populations (for example, social anxiety disorder and harmful alcohol use) and healthy volunteers.

Yonamine's publications explore a consistent set of questions: whether single-dose or acute administration of ayahuasca can modulate symptoms and self-perception in social anxiety, influence harmful alcohol use in young adults, and alter social cognition and emotion-recognition processes. More mechanistic or translational studies in their portfolio probe potential interactive effects between ayahuasca (and its serotonergic 5-HT2A-mediated actions) and the endocannabinoid system, including exploratory work combining ayahuasca and cannabidiol. Across these studies Yonamine has emphasised feasibility, safety, and early efficacy signals to inform larger, definitive trials.