John Krystal
Professor of Psychiatry
Papers
Trials
Key Impact
A leading clinician-scientist who helped translate NMDA-receptor antagonism into rapid-acting antidepressant treatments and who applies neuroimaging and translational methods to understand psychedelic and dissociative pharmacology.
Background & Research
John H. Krystal, MD, is a psychiatrist and neuroscientist based at Yale School of Medicine whose work bridges psychopharmacology, neuroimaging and clinical trials. He played an early and influential role in demonstrating the rapid antidepressant effects of subanaesthetic ketamine and has led and co‑authored multiple clinical studies and trials examining ketamine and other novel agents across mood, trauma-related and personality disorders. Krystal's research agenda combines experimental medicine approaches (including placebo‑controlled trials, open‑label and dose‑escalation designs) with multimodal neuroimaging to probe mechanisms of action and biomarkers of clinical response.