Jaime Crippa

Jaime A. S. Crippa is a clinical neuropsychopharmacologist affiliated with groups including the Human Neuropsychopharmacology Group at the Sant Pau Institute of Biomedical Research. His work spans clinical trials, pilot randomised studies and multimodal neuroimaging to investigate the psychopharmacology, therapeutic potential and neural mechanisms of classical psychedelics—particularly ayahuasca—and their interactions with other neuromodulatory systems.

Crippa has contributed influential preliminary clinical reports and imaging studies demonstrating rapid antidepressant effects of a single dose of ayahuasca in patients with recurrent depression, and has characterised post-acute ('after‑glow') neurometabolic and functional connectivity changes linked to enhanced mindfulness capacities. He has also explored putative interactions between 5‑HT2A receptor agonism and the endocannabinoid system, and conducted feasibility work on combined ayahuasca–cannabidiol effects on social cognition. Methodologically, his portfolio emphasises SPECT, fMRI and other brain‑imaging approaches alongside controlled human experimental and pilot clinical designs, informing mechanistic models of serotonergic psychedelic action and their therapeutic translation.