František Tylš

František Tylš is a psychopharmacologist whose recent work focuses on the behavioural and neurophysiological effects of psilocybin and its active metabolite psilocin across species. His body of work spans controlled studies in healthy human volunteers (including event-related potentials such as P300 and mismatch negativity, declarative memory consolidation, and sleep measures) and preclinical investigations addressing sensory and sex-dependent behavioural responses in rodents.

Tylš's contributions are characterised by a translational approach that integrates EEG-based cognitive electrophysiology, sleep research, and animal behavioural pharmacology to elucidate how serotonergic psychedelics alter sensory processing, higher-order cognition, and sleep architecture—areas with direct relevance to proposed antidepressant mechanisms and the neurobiology of altered perception. His publications include cross-species demonstrations of psilocin-induced visual distortions and investigations into how daytime psilocybin administration affects sleep and memory consolidation.