Brandon Weiss

Brandon Weiss is a clinical researcher affiliated with the Johns Hopkins Centre for Psychedelic and Consciousness Research whose work centres on how classic psychedelics produce enduring changes in personality, clinical outcomes and behaviour. His research portfolio spans experimental studies in healthy volunteers and clinical trials in depressive and anxiety disorders, with particular emphasis on measuring personality change, expectancy and suggestibility as moderators of therapeutic response. Weiss has contributed to comparative clinical work examining psilocybin-assisted therapy versus standard antidepressant treatment and to observational and mixed-methods investigations of ceremonial ayahuasca and its effects on interpersonal and antagonistic personality features.

Weiss has also published on safety, adverse events and psychiatric risk in psychedelic research, and on broader pharmacological and historical perspectives on ayahuasca. His methodological approach combines controlled clinical trial designs, psychometric assessment of personality and suggestibility, and attention to set-and-setting variables, positioning him at the intersection of clinical outcome research and mechanistic investigations of psychedelic-assisted therapies. He frequently collaborates with established research groups in the field and contributes to reviews and commentary that inform best practices for participant assessment and risk monitoring.