Outcome MeasureDepression

MADRS-SI

Montgomery–Åsberg Depression Rating Scale – Suicidal Ideation Item

2 Papers in Blossom

Clinical Thresholds

No suicidal ideation

Weary of life, fleeting thoughts

Better off dead, suicidal thoughts

Explicit plans or active ideation

No suicidal ideation

Score 0–0

Weary of life, fleeting thoughts

Score 1–2

Better off dead, suicidal thoughts

Score 3–4

Explicit plans or active ideation

Score 5–6

Outcome Data Across Studies

Reported results for MADRS-SI across 2 studies with quantitative data.

Outcome data across 11 study arm–timepoint observations
					SD
The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial. 2019Primary	Ayahuasca(experimental)	0	14	—	—	—
The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial. 2019Primary	Placebo(inactive)	0	15	—	—	—
The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial. 2019Primary	Ayahuasca(experimental)	1	14	—	—	—
The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial. 2019Primary	Placebo(inactive)	1	13	—	—	—
The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial. 2019Primary	Ayahuasca(experimental)	2	13	—	—	—
The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial. 2019Primary	Placebo(inactive)	2	14	—	—	—
The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial. 2019Primary	Ayahuasca(experimental)	7	14	—	—	—
The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial. 2019Primary	Placebo(inactive)	7	15	—	—	—
Magnesium-ibogaine therapy in veterans with traumatic brain injuries 2024Exploratory	Ibogaine + magnesium(experimental)	0	30	47.0	—	—
Magnesium-ibogaine therapy in veterans with traumatic brain injuries 2024Exploratory	Ibogaine + magnesium(experimental)	5	30	0.0	—	—

Papers Using MADRS-SI

Open Accessindividual

Magnesium-ibogaine therapy in veterans with traumatic brain injuries

This observational study (n=30) evaluates ibogaine (up to 980mg/70kg) in combination with magnesium (1-2 hours before and 12 hours later) in male Special Operations Forces veterans with predominantly mild traumatic brain injury (mTBI). The study assessed changes in disability, PTSD, depression, and anxiety immediately and one month after treatment using various scales. Results show significant improvements in functioning and psychological symptoms with no serious adverse events.

Published: January 5, 2024
Journal: Nature Medicine
Authors: Cherian, K. N., Keynan, J. N., Anker, L., Faerman, A., Brown, R. E., Shamma, A., Keynan, O., Coetzee, J. P., Batail, J. M., Phillips, A., Bassa, N. J., Sahlem, G. L., Inzunza, J., Millar, T., Dickinson, J., Rol, C. E., Keller, J., Adamson, M., Kratter, I. H., Williams, N. R.

Open Accessindividual

The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial.

This secondary analysis of a double-blind, parallel-arm, randomised placebo-controlled trial (n=29) investigates the impact of ayahuasca on suicidality (SI) in individuals with treatment-resistant depression (TRD). It found that ayahuasca may show potential as a fast-acting and innovative intervention for SI, but didn't find significant results (only a trend with a large effect size). This is the first study to investigate the use of ayahuasca for SI.

Published: November 19, 2019
Journal: Frontiers in Pharmacology
Authors: Araújo, D. B., Arcoverde, E., Hallak, J. E., Maia-de-Oliveira, J. P., Palhano-Fontes, F., Zeifman, R. J.

Quick Facts

Full Name: Montgomery–Åsberg Depression Rating Scale – Suicidal Ideation Item
Domain: Depression
Papers Indexed: 2
Score Range: 0–6
Interpretation: Lower = better
Unit: points

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