A PRISMA-guided systematic review of ergolamines, simple tryptamines and phenylethylamines (33 studies from 3,032 records) finds that classic psychedelics are active at very low doses, non‑addictive and generally only harmful at extremely high doses, with no established lethal dose for LSD or psilocybin. MDMA appears to carry the greatest apparent toxicity—likely confounded by recreational misuse—and the authors emphasise that risk is strongly modulated by set and setting.
- Published
- Journal
- Toxics
- Authors
- Henríquez-Hernández, L. A., Rojas-Hernández, J., Quintana-Hernández, D. J., Borkel, L. F.