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25 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Ayahuasca-Inspired DMT/HAR Formulation Reduces Brain Differentiation Between Self and Other Faces

This secondary analysis of an RCT brain imaging (EEG) study (n=30) examines how DMT/HAR and Harmine alone affect face recognition and self-processing in healthy males using a visual oddball task. It finds DMT/HAR enhanced early visual processing while reducing neural differentiation between self and other faces at posterior sites, suggesting psychedelics reshape rather than erase self-boundaries while preserving socially meaningful representations.

Published
Journal
NeuroImage
Authors
Suay, D., Aicher, H. D., Kometer, M., Mueller, M. J., Caflisch, L., Hempe, A., Steinhart, C., Elsner, C., Wicki, I., Müller, J., Meling, D., Dornbierer, D. A., Scheidegger, M., Bottari, D.
Open Accessindividual

Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields

This within-subject MRI study (n=11) finds that inhaled DMT increases the mean population receptive field (pRF) sizes in the peripheral visual field of the primary visual cortex (V1). Documented by the Hallucinogen Rating Scale (HRS), this effect explains visual perceptual distortions like field blurring and tunnel vision, and supports the role of 5-HT2A receptor activation in controlling visual cortex activity.

Published
Journal
NeuroImage
Authors
Pais, M., Teixeira, M., Soares, C., Lima, G. M., Rijo, P., Cabral, C., Castelo-Branco, M.
Open Accessindividual

Conflict monitoring and emotional processing in 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine users - A comparative neurophysiological study

This comparative study (n=38 METH users, n=42 MDMA users, n=83 controls) examines the impact of chronic METH and MDMA use on conflict control processes in social-affective contexts. Both METH and MDMA users exhibit reduced behavioral effects in cognitive-emotional conflict processing, particularly regarding anger content. These effects are associated with stronger P3 event-related potential modulations, suggesting altered decision-making and stimulus-response mapping, potentially linked to noradrenergic dysfunctions. Understanding the role of noradrenaline in chronic users of substituted amphetamines represents a significant direction for future research in this area.

Published
Journal
NeuroImage
Authors
Opitz, A., Zimmermann, J., Cole, D. M., Coray, R. C., Zachäi, A., Baumgartner, M. R., Steuer, A. E., Pilhatsch, M., Quednow, B. B., Beste, C., Stock, A. K.
Open Accessindividual

Shared functional connectome fingerprints following ritualistic ayahuasca intake

This fMRI study (n=21) of people who regularly use ayahuasca within the Santo Daime church finds that during the experience, changes in functional connectivity (FC, how brain areas communicate) indicate on the scans more similarity between them (so less 'unique' FC). The authors use an analogy that each person still has their own hairstyle, but instead of wearing different coloured t-shirts, all are now wearing the same shirt.

Published
Journal
NeuroImage
Authors
Mallaroni, P., Mason, N. L., Kloft, L., Reckweg, J. T., Van Oorsouw, K., Toennes, S. W., Tolle, H. M., Amico, E., Ramaekers, J. G.
Open Accessindividual

LSD-induced changes in the functional connectivity of distinct thalamic nuclei

This re-analysis study (n=20) investigated the impact of acute LSD (75μg) administration on thalamocortical connectivity in healthy volunteers. The study utilized structural and resting-state fMRI to examine the thalamus at the nucleus-specific level. LSD intake was found to increase functional connectivity between the thalamus's ventral complex, pulvinar, and non-specific nuclei, particularly with sensory cortices such as somatosensory and auditory networks, as well as parts of the associative cortex dense in serotonin type 2A receptors. The study also reported decreased connectivity between the striatum and thalamus.

Published
Journal
NeuroImage
Authors
Pizzi, S. D., Chiacchiaretta, P., Sestieri, C., Ferretti, A., Tullo, M. G., Penna, S. D., Martinotti, G., Onofrj, M., Roseman, L., Slater, C. B. T., Nutt, D. J., Carhart-Harris, R. L., Sensi, S. L.
Open Accessindividual

Classical and non-classical psychedelic drugs induce common network changes in human cortex

This fMRI analysis study (n=74 total) looks at how three different drugs -; nitrous oxide, ketamine, and lysergic acid diethylamide (LSD) -; affect the way different parts of the brain communicate with each other. By comparing brain scans taken before and during drug use, the study found that all three drugs reduced connectivity within certain networks in the brain, while enhancing connections between different networks. These effects were seen in areas of the brain that are important for our conscious experiences.

Published
Journal
NeuroImage
Authors
Dai, R., Larkin, T. E., Huang, Z., Tarnal, V., Picton, P., Vlisides, P. E., Janke, E., Mckinney, A., Hudetz, A. G., Harris, R. E., Mashour, G. A.

Quick Facts

Papers Indexed
25
h-Index
438
Open Access
Yes
Publisher
Elsevier
Country
United States
Website
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