Indole Alkaloid

Ibogaine

A unique indole alkaloid with complex pharmacology, investigated primarily for its capacity to interrupt substance use disorders and withdrawal.

Pharmacology & Mechanism of Ibogaine

Detailed pharmacological information is currently being assembled by our research team.

Quick Facts

  • Highest PhasePhase II
  • Key IndicationsOpioid Use Disorder (OUD), Alcohol Use Disorder (AUD)
  • Primary MechanismNMDA Antagonist / Kappa Opioid Agonist / SERT Inhibitor
  • Session Duration24-48 hours
  • OriginBotanical (Tabernanthe iboga)

Connected Research

Recent clinical trials and academic literature investigating Ibogaine.

Recent Clinical Trials

View all trials →
CompletedPhase I

Noribogaine Therapy for Relief of Opioid withdrawal, Phase 1B; A Phase 1B, Single Center, Randomized, Double-Blind, Placebo-Controlled, Ascending Single Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Noribogaine in Opioid Dependent Participants Seeking to Discontinue Methadone Opioid Substitution Treatment (OST)

CompletedPhase II

The Efficacy of Ibogaine in the Treatment of Addiction; an open label, single fixed dose pilot-study of the efficacy of ibogaine in opioid-dependent subjects

WithdrawnPhase II

Trifecta Research Study

Active not recruitingPhase NA

Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure

CompletedPhase II

Preliminary Efficacy and Safety of Ibogaine in the Treatment of Methadone Detoxification

CompletedPhase II

Ibogaine in the Treatment of Alcoholism: a Randomized, Double-blind, Placebo-controlled, Escalating-dose, Phase 2 Trial

Recent Academic Papers

View all papers →

The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation

Published
Journal
Nature Neuroscience

Magnesium-ibogaine therapy effects on cortical oscillations and neural complexity in veterans with traumatic brain injury

Published
Journal
Nature Mental Health

The pharmacokinetics and pharmacodynamics of ibogaine in opioid use disorder patients

Published
Journal
Journal of Psychopharmacology

Magnesium-ibogaine therapy in veterans with traumatic brain injuries

Published
Journal
Nature Medicine

Main targets of ibogaine and noribogaine associated with its putative anti-addictive effects: A mechanistic overview

Published
Journal
Journal of Psychopharmacology

Three Decades of Research on the Development of Ibogaine Treatment of Substance Use Disorders: A Scientometric Analysis

Published
Journal
Journal of Psychoactive Drugs