Tryptamine

DMT

A powerful, short-acting tryptamine psychedelic found in many botanical sources, known for rapid onset and intense subjective experiences.

Pharmacology & Mechanism of DMT

Detailed pharmacological information is currently being assembled by our research team.

Quick Facts

  • Highest PhasePhase II
  • Key IndicationsMajor Depressive Disorder (MDD), Alcohol Use Disorder (AUD)
  • Primary Mechanism5-HT2A Agonist
  • Session Duration15-30 minutes (Inhaled/IV)
  • OriginBotanical / Synthesised

Connected Research

Recent clinical trials and academic literature investigating DMT.

Recent Clinical Trials

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CompletedPhase I

A study on the safety and effects of the drug DMT in healthy smoking individuals

CompletedPhase I

Safety, blood levels and effects of N,N-dimethyltryptamine [DMT (SPL026)] in healthy participants that have taken psychedelic substances before (Part A) and in healthy participants with little to no psychedelic experience (Part B)

CompletedPhase I

Safety, tolerability, pharmacokinetics, pharmacodynamics and exploratory efficacy of intravenous dosing of SPL026 drug product (N, N-dimethyltryptamine fumarate; DMT Fumarate [A Serotonergic Psychedelic]) alone or in combination with selective serotonin reuptake inhibitors in patients with major depressive disorder

CompletedPhase I

Safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and effects of intravenous (IV) and intramuscular (IM) dosing of SPL028 (deuterated DMT fumarate [a serotonergic psychedelic]) in healthy volunteers and participants with major depressive disorder (MDD)

Active not recruitingPhase NA

Understanding Neuroplasticity Induced by TrYptamines (UNITy): the effects of dimethyltryptamine (DMT) on drinking

RecruitingPhase NA

Antidepressant Response of DMT Masked With Propofol (DMT4D)

Recent Academic Papers

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Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine

Published
Journal
Journal of Cognitive Neuroscience

A novel psychedelic 5-HT2A receptor agonist GM-2505: The pharmacokinetic, safety, and pharmacodynamic profile from a randomized trial healthy volunteer

Published
Journal
Journal of Psychopharmacology

Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics

Published
Journal
ACS Chemical Neuroscience

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences

Published
Journal
Neuropsychopharmacology

Ayahuasca-inspired DMT/harmine formulation alters creative thinking dynamics during artistic creation

Published
Journal
Journal of Psychopharmacology

DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers

Published
Journal
Frontiers in Psychiatry